Search for new biologically active compounds based on 6-methyluracil-5-sulfochloride and alcohols

Synthesis of Some Nitrogen Functional Derivatives of 5-substituted-6-azauracil as Biologically Active Compounds

3-Arylhydrazono-2,4-dioxo-4-phenylbutanoates have been prepared by the coupling of benzoylpyruvate with aryldiazonium chlorides. Reactions of the 3-arylhydrazono-2,4- dioxo-4-phenylbutanoates with 1-aminoguanidine, semicarbazide, and thiosemicarbazide gave 5-substituted 2-imino-6-azauracil (3a), 6-azauracil (3b), and 2-thio-6-azauracil (3c), respectively. The analytical data of these compounds ...

synthesis of some nitrogen functional derivatives of 5-substituted-6-azauracil as biologically active compounds

Search for new compounds and biologically active substances from Chinese marine organisms*

In search of new pharmaceutically valuable substances from marine organisms, we have been engaged in chemical studies on the constituents of corals, sponges and algae collected in the South China Sea. This paper summarizes some of our research results. Terpenes, nitrogen-containing compounds and polyhydroxylated sterols are mainly discussed. The corals, marine sponges and algae are abundant nat...

Effect of Cinnamon and its Biologically Active Compounds on the Components and Symptoms of Metabolic Syndrome

Background and purpose: Metabolic syndrome refers to a set of diseases including insulin resistance, high blood glucose levels, obesity, high blood pressure, and dyslipidemia. The cinnamon plant is a member of the Lauraceae family and is considered a universal medicinal plant. Traditional medicine studies reported the therapeutic effects of this plant in the reduction of blood glucose levels, b...

Oligonucleotides and polynucleotides as biologically active compounds.

Nucleic acids are involved in the most important processes occurring in living cells and possess an enormous potential for specific interactions with different biopolymers. Specificity of recognition of DNA and RNA species by complementary nucleic acids is unique in the world of biopolymers. A great number of the proteins involved in processes of replication, transcription, and translation are ...